Nanomedicine Targeting to Activated Neutrophils and Neutrophil-Platelet Complexes Provides Effective Thromboprotection

On Monday, July 19, 2021, Dillon Bohinc of Case Western Reserve University School of Medicine in Cleveland presented results from research aimed at developing a therapeutic strategy that specifically targets activated, pathogenic neutrophil subsets without the ubiquitous inhibition of resting cells.

CRISPR Edited Megakaryocytes for Rapid Screening of Platelet Gene Functions

Emilie Montenont, Ph.D., of The University of Utah commented that the goal of her research was to develop and define the strengths and limitations of a rapid and systematic approach to screen genes for platelet functions in primary megakaryocytes called CRIMSON.

Building a Better NET: Neutrophil Extracellular Trap Stabilization to Enhance Microbe Entrapment

When present in high concentrations, NETs injure the microvasculature and induce organ dysfunction. Recently, NET degradation products (NDPs), including cfDNA, histones, and MPO, have been identified in patients with COVID-19, and higher levels have been associated with increased disease severity.

The Role of Platelet Transfusions to Manage Bleeding: Lessons From Randomized Trials (Including Neonates and Children)

Platelet transfusions are the second most commonly administered cellular blood component, after red cells. The focus of much of the research on the appropriate use to date has been in adult patients with hematological cancers, looking at questions of optimal dose or safe platelet count threshold.

Personalized Cancer-Associated Thrombosis Risk Assessment: Integration of Plasma Proteomics, Clinical Characteristics, and Machine Learning

Numerous studies have established that thrombosis is a common complication for cancer patients.  Unfortunately, a uniform biomarker does not exist and the current risk scoring methods exhibit modest accuracy.  Machine learning may be able to help.