Building a Better NET: Neutrophil Extracellular Trap Stabilization to Enhance Microbe Entrapment

When present in high concentrations, NETs injure the microvasculature and induce organ dysfunction. Recently, NET degradation products (NDPs), including cfDNA, histones, and MPO, have been identified in patients with COVID-19, and higher levels have been associated with increased disease severity.

The Role of Platelet Transfusions to Manage Bleeding: Lessons From Randomized Trials (Including Neonates and Children)

Platelet transfusions are the second most commonly administered cellular blood component, after red cells. The focus of much of the research on the appropriate use to date has been in adult patients with hematological cancers, looking at questions of optimal dose or safe platelet count threshold.

Personalized Cancer-Associated Thrombosis Risk Assessment: Integration of Plasma Proteomics, Clinical Characteristics, and Machine Learning

Numerous studies have established that thrombosis is a common complication for cancer patients.  Unfortunately, a uniform biomarker does not exist and the current risk scoring methods exhibit modest accuracy.  Machine learning may be able to help.

Diagnosing Inherited Platelet Disorders: Immunofluorescence on the Blood Smear in Comparison With Genetic Testing

On Sunday, July 19, 2021, Carlo Zaninetti of the Institut für Immunologie und Transfusionsmedizin, Universitätsmedizin Greifswald in Germany, presented results on the comparison between immunofluorescence and genetic testing for diagnosing inherited platelet disorders (IPDs).

Platelet microRNAs Inhibit Primary Tumor Growth via Broad Modulation of Tumor Cell mRNA Expression in Ectopic Pancreatic Cancer in Mice

On Monday, July 19, 2021, Larry Goldfinger of Thomas Jefferson University in Philadelphia presented follow-up research on the inhibitory role for platelets in solid tumor growth mediated by tumor infiltration of platelet microvesicles (microparticles), which are enriched in platelet-derived microRNAs (miRNAs).