Activated platelets are thought to provide the majority of procoagulant PS, whose externalization is regulated by the phospholipid scramblase transmembrane protein 16F (TMEM16F). This was one of the goals of the research presented by Alec Schmaier, M.D., Ph.D.
On Sunday, July 18, 2021, Cara Sake of the Colorado School of Mines presented results from research aimed at generating the first metabolic flux map of resting and thrombin-activated platelets based on intracellular isotope profiling.
Evidence suggests that DTRI-177 may allosterically modulate IXa function and also possibly interfere with the IXa/VIIIa interaction within intrinsic Xase, but this is still unknown.
Maki Ishizuka and her group at the Children's Hospital of Philadelphia in Philadelphia had stated that platelet factor 4 (PF4), a platelet-specific chemokine, aggregates NETs, enhancing bacterial capture while protecting NETs from nuclease degradation, thereby limiting NDP release. Her aim was to look further into the effect of PF4 on NET-mediated entrapment of coronaviruses.